Fresh analysis reveals that individuals who come off popular slimming jabs like Wegovy and Mounjaro tend to recover reduced body mass much more quickly than those who halt conventional lifestyle plans.
Findings released in a prominent medical journal points out that while obese individuals often shed a large proportion of their total mass while using the jabs, the mass returns at an estimated rate of nearly a kilo each month once they quit.
"Users using these treatments should be aware of the risk of quick rebound weight gain when the treatment is stopped," warns researcher Dr. Susan Jebb.
This pace of recovery means a return to pre-treatment weight within about one and a half years.
Comparing Therapies
The research, which reviewed dozens of studies involving over 9,000 of patients, contrasted the results of these new drugs with other pills.
Researchers emphasize that individuals who shed pounds through dieting usually have a slower creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Rapid Rebound
Doctors suggest the mode of action of the injections explains the amplified weight return.
GLP-1 drugs imitate a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Long-term administration of GLP-1 concentrations several times higher than normal could lead to the system to produce less of its endogenous hormone, and could lessen sensitivity to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication leads to hunger is uncontrolled, making excessive eating far more likely."
An Ongoing Disease?
The NHS suggest the jabs for individuals with weight-linked health risks, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, due to the significant potential of relapse, the treatment is often life-long.
This opinion is reinforced by drug manufacturers, who say that the findings "highlight the chronic character of obesity," similar to managing conditions like hypertension.
Patient Experiences
Individuals who have discontinued the medication explain a sudden resurgence of appetite.
"It felt as if a trigger that goes on and I was suddenly extremely hungry," recalled a patient.
This challenge is exacerbated if users have not adopted sustainable lifestyle or habit modifications during therapy.
Significant Interest
Survey data suggest that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with desire being substantial.
- Use is greater among women compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than the NHS.
In conclusion, experts stress that while these medications are powerful tools for weight loss, they are not a permanent fix and lasting health benefits relies on integrated behavioural support.
